分子流行病学在职业性致癌研究中的应用

作者综合描述了分子流行病学基本概念的主要内容与传统流行病学的差异。阐明：１．分子流行病学是分子生物学与流行病学相结合的边缘科学；２．化学致癌物在体内的生成量及其与生物大分子结合的生物有效量与癌症发生有关；３．染色体异常综合症是癌症早期的生物效应；癌基因激活，抗癌基因失活是被启动了的细胞恶性转化所必须的；４．先天和后天获得的宿主因素可影响人体对致癌剂的易感性；５．建立生物样品库，进行前瞻队列研究可提供连续性观察结果及癌前癌后比较，为因果关系的时间顺序提供有效的依据

Application of molecular epidemiology in occupational studies

This paper described the concept of molcualr epidemiology, it's differences from traditional epidemiology and what the author learned from conducting molecular epidemiology recently.1 Molecular epidemiology is the bordline subject in combination of molecular biology with epidemiology. 2 The level of chemical carcinogen formed in vivo and the amount of combination of chemical carcinogen either in the level from vivo or in biologic effective dose of combination of chemical carcinogen with macromolecular are all related to cancer development. 3 The syndrome of chromosome aberration is an early biologic effect in cancer process and oncogen activation or suppressing gene inactivation might be necessary for malignant transformation from initiated cell. 4 Individaul susceptibility could be affected by host and aqured factors. 5 Biologic bank could provide continuous observation and comparasion between before and after cancer formation.