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Transplantation of Human Bone Marrow Mesenchymal Stem Cell Ameliorates the Autoimmune Pathogenesis in MRL/lpr Mice |
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| Authors: | Kangxing Zhou Huayong Zhang Ouyang Jin Xuebing Feng Genhong Yao Yayi Hou Lingyun Sun |
| Affiliation: | Kangxing Zhou1,3,Huayong Zhang1,Ouyang Jin1,Xuebing Feng1,Genhong Yao1,Yayi Hou2 , Lingyun Sun1,4 1Department of Rheumatology , Immunology,The Affiliated Drum Tower Hospital of Nanjing University Medical School,321 Zhongshan Road,Nanjing,Jiangsu 210008,China,2Immunology Laboratory,Nanjing University Medical School,22 Hankou Road,Jiangsu 210093 |
| Abstract: | Recent evidence indicates that mesenchymal stem cells (MSC) possess immunosuppressive properties both in vitro and in vivo. We previously demonstrated the functional abnormality of bone marrow derived MSC in patients with systemic lupus erythematosus (SLE). In this study, we aimed to investigate whether transplantation of human bone marrow derived MSC affects the autoimmune pathogenesis in MRL/lpr mice. We found that human MSC from healthy donors reduced the proliferation of T lymphocytes from MRL/lpr mice ... |
| Keywords: | systemic lupus erythematosus mesenchymal stem cell transplantation |
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