| 睾酮对低氧小鼠红细胞比容和血清促红细胞生成素的影响 |
| |
| 引用本文： | 曲立文,孟宪法,姜如冈.睾酮对低氧小鼠红细胞比容和血清促红细胞生成素的影响[J].医学理论与实践,2001,14(7):583-584. |
| |
| 作者姓名： | 曲立文 孟宪法 姜如冈 |
| |
| 作者单位： | 1. 大连大学医学院 116622
2. 天津医科大学 300070 |
| |
| 基金项目： | 本研究为辽宁省教委高等学校科学研究项目,编号:9649311284. |
| |
| 摘 要： | 为了观察性激素对红细胞生成的作用,应用低压舱(0.42atm,22h/d)分别给小鼠注射人重组促红细胞生成素(rhEPO)、睾酮、皮质醇,检测红细胞比容(Hct)和血清促红细胞生成素(sEPO)的变化。结果表明:低氧6d后,各组sEPO均显著升高(P<0.05);注射rhEPO或睾酮组的Hct显著增加(P<0.05);注射rhEPO或睾酮组的Hct显著增加(P<0.05),而注射皮质醇组Hct改变不显著(P>0.05)。
|
| 关 键 词： | 睾酮 促红细胞生成素 红细胞比容小鼠 低氧 |
| 修稿时间： | 2001年3月28日 |
Effects of Testosterone on Hematocrit and Serum Erythropoietin in Mice with Hypoxia |
| |
| QU Liwen,MENG Xianfa,JIANG Rugang
Medical College Dalian University Dalian
Tianjin Medical University.Effects of Testosterone on Hematocrit and Serum Erythropoietin in Mice with Hypoxia[J].The Journal of Medical Theory and Practice,2001,14(7):583-584. |
| |
| Authors: | QU Liwen MENG Xianfa JIANG Rugang
Medical College Dalian University Dalian
Tianjin Medical University |
| |
| Institution: | QU Liwen1,MENG Xianfa1,JIANG Rugang2
1 Medical College Dalian University Dalian 116622
2 Tianjin Medical University |
| |
| Abstract: | The purpose of the present study was to investigate the effects of sexual hormone on erythropoiesis under hypoxia of mice,injected with rhEPO,testosterone,cortisol by use of hypoxic chamber(0.42atm,22h/d)respectively,in order to examine the changes of hematocrit( Hct) and serum EPO( sEPO). The results showed that sEPO of the every group mice with hypoxia was increased equally after 6 days obviously( P < 0.05), moreover, Hct of the mice injected by rhEPO of testosterone was increased clearly (P <0.05) ,but Hct of the mice injected by cortisol did not remarkably change(P<0.05). |
| |
| Keywords: | Testosterone Elythropoietin (EPO) Hematocrit(Hct) Mice Hypoxia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
