| 精子DNA完整性检测的临床应用 |
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| 引用本文： | 宋学茹,姜珊,白晓红,岳天孚. 精子DNA完整性检测的临床应用[J]. 国外医学(计划生育．生殖健康分册), 2011, 0(1) |
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| 作者姓名： | 宋学茹 姜珊 白晓红 岳天孚 |
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| 作者单位： | 天津医科大学总医院妇产科生殖中心; |
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| 摘 要： | 男性生育力受到许多因素的影响,其中精子DNA损伤一直是生殖医学领域研究的热点之一。精子线粒体、核DNA损伤会导致受精失败或影响受精后原核的形成、胚胎着床及子代的健康。目前,定量检测精子中异常DNA数量的方法有多种,虽然尚不理想,但各有其临床应用价值。精子DNA损伤分析比传统精液常规分析参数更稳定、更敏感。胞浆内单精子注射(ICSI)前先对精子DNA进行评估十分必要。精子DNA损伤程度是新的评价精液质量和预测生育能力的指标。
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| 关 键 词： | 不育 男(雄)性 精子 DNA 线粒体 精液 生殖技术 辅助 妊娠结局 |
Assessment of Sperm DNA Integrity and Clinical Management |
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| SONG Xue-ru,JIANG Shan,BAI Xiao-hong,YUE Tian-fu.Reproductive Medical Center,Tianjin Medical University General Hospital,Tianjin ,China. Assessment of Sperm DNA Integrity and Clinical Management[J]. , 2011, 0(1) |
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| Authors: | SONG Xue-ru JIANG Shan BAI Xiao-hong YUE Tian-fu.Reproductive Medical Center Tianjin Medical University General Hospital Tianjin China |
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| Affiliation: | SONG Xue-ru,JIANG Shan,BAI Xiao-hong,YUE Tian-fu.Reproductive Medical Center,Tianjin Medical University General Hospital,Tianjin 300052,China |
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| Abstract: | The male fertility is affected by many factors and sperm DNA damage is one of the hot spots in ART.Spermatozoa mitochondria and nucleus DNA damage have negative effects on normal fertilized process,pronucleus shaping,implantation and offspring health.At present,sperm DNA damage can be detected by more and more methods,although none of these provides an ideal method to assess sperm DNA integrity,and each has its clinical application,which are more stable and more sensitive than the conventional analysis of s... |
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| Keywords: | INFERTILITY MALE Spermatozoa DNA mitochondrial Semen Reproductive techniques assisted Pregnancy outcome |
| 本文献已被 CNKI 等数据库收录！ |
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