附睾特异蛋白与精子功能的研究进展

鉴定精子特异蛋白的目的是阐明其在生殖过程中的作用,将其作为有效调控的靶点。哺乳动物的精子在睾丸的曲细精管内生成后,虽然形态上已成为蝌蚪状,但并不具备运动和识别卵子并使其受精的能力。精子必须经过附睾内的加工才能成熟,即精子的附睾成熟。该过程主要是修饰精子膜表面的蛋白,随着精子在附睾管腔中的运行,某些蛋白被移除或结合其上,还有经历糖基化或磷酸化等修饰。因此,对附睾中蛋白的鉴定研究,特别是附睾特异合成的蛋白,始终是揭示精子功能的重要切入点之一。综述近年对附睾特异蛋白参与精子成熟以及保护精子的较系统的研究。

Study on the Relationship of Epididymis-specific Protein and Sperm Function

Charactering the sperm specific proteins is to elucidate the function in the process of reproduction and to develop them as effective targets for reproductive regulation.Mammalian sperm after spermiogenisis in testis seminiferous tubules,although they are tadpole-like,are neither able to swim nor to fertilize the egg.Sperm must undergo modification in epididymis to be mature,which is called epididymal sperm maturation.This process mainly includes the sperm membrane protein modification.During sperm travelin...