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Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease
Authors:Swardfager W  Herrmann N  Marzolini S  Saleem M  Shammi P  Oh P I  Albert P R  Daigle M  Kiss A  Lanctôt K L
Institution:a Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
b Neuropsychology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
c Division of Clinical Pharmacology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
d Clinical Epidemiology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
e Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
f Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
g Toronto Rehabilitation Institute, Toronto, Ontario, Canada
h Ottawa Hospital Research Institute (Neuroscience), University of Ottawa, Ottawa, Ontario, Canada
Abstract:

Objective

To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD).

Methods

Serum BDNF concentrations were assayed by ELISA and fitness was assessed using a standardized exercise stress test. The Mini Mental Status Examination (MMSE), California Verbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.

Results

In subjects with CAD (n = 88; 85.2% male, mean age 62.8 ± 10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β = .305, p = .013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1, 87) = 15.406, p < .0005) and better performance on the Digit Symbol-Coding task (F(1, 87) = 9.620, p = .003). IL-6, TNF-α and the val66met genotype did not influence these results.

Conclusion

Serum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.
Keywords:Brain derived neurotrophic factor  BDNF  Cognition  Cardiopulmonary fitness  Coronary artery disease  Memory  Executive function  Psychomotor processing speed
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