子宫内膜癌患者血清TK1检测的临床意义

目的：探讨血清细胞质胸苷激酶1（TK1）检测在子宫内膜癌诊治中的临床价值。方法：利用免疫印迹增强化学发光法（ECLA）检测154例子宫内膜癌患者血清TK1的含量，同时检测130例子宫内膜良性疾病和121名健康人血清中的TK1含量。结果：子宫内膜癌患者TK1水平[3.14（1.87—3.95）pmol／L]显著高于子宫内膜良性疾病组[1.31（0.95—1.63）pmol／L]和正常对照组[1.24（0.62—1.49）pmol／L]（P〈0.01）；而子宫内膜良性疾病组和正常对照组之间差异无统计学意义（P〉0.05）。154例子宫内膜癌患者手术后血清TK1水平明显下降。子宫内膜癌患者血清TK1阳性率（61.7％）远高于其他生殖道肿瘤标志物[癌胚抗原（CEA）（15.6％）]、糖抗原[CA199（14.5％），CA125（17.9％）]。结论：血清TK1检测在子宫内膜癌诊断、预后判断、疗效监测等方面具有一定的临床应用价值。

Significance of serum thymidine kinase in patients with endometrium carcinoma

Objectlve：To investigate the diagnostic value of sermn thymidine kinase 1 （sTK1） in endometrimn cancer. Methods：The levds of sTK1 in 154 patients with endometrium cancer, 130 with benign disease and 121 normal controls were determined by enhanced chemi - luminescence assay. Results：The levels of STK1 in patients with endometrimn carcinoma 13.14（ 1.87 -3.95）pmol/L1 were much higher than those in patients with benign disease [1.31 （0.95 - 1. 63 ） pmol/L] and normal eoatrols [1.24 （0.62 - 1. 49 ） pmol/L] （P 〈 0.01 ） , but there was no significant difference between patients with benign disease and normal controls （P 〉 0.05）. The level of STK1 declined significantly one month after operation. The positive rale of STK1 in patients with endometrimn cancer（61.7% ）was much higher than other digestive tmnor marker [ careinoembryonic antigen（CEA） （ 15.6% ） 1 , carbohydrate antigen [ CA199 （ 14.5% ） , CA125 （ 17.9% ） 1 - Conclusion ：The detection of STK1 may have value in the diagnosis, monitoring and prognosis of endometrium cancer.