| Caveolin - 1 在消化系统肿瘤中的研究进展简 |
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| 引用本文： | 张坤东,黄陈,裘正军. Caveolin - 1 在消化系统肿瘤中的研究进展简[J]. 现代肿瘤医学, 2014, 0(1): 223-226 |
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| 作者姓名： | 张坤东 黄陈 裘正军 |
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| 作者单位： | 上海交通大学附属第一人民医院普外科,上海市胰腺疾病重点实验室,上海交通大学胰腺癌诊治中心,上海200080 |
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| 基金项目： | 国家自然科学基金项目（编号：81101844,81210108027）;上海市人才发展资金项目（编号：2012040）;上海市浦江人才计划项目（编号：13PJD024）;上海交通大学晨星青年学者项目 |
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| 摘 要： | 细胞窖蛋白-1（Caveolin—1）为分子量21—24kD的膜蛋白，是Caveolae的主要结构成分，参与胆固醇运输、囊泡转运，细胞信号转导等过程，同时与肿瘤的发生、发展和转移密切相关。本文介绍Caveolin-1的结构和功能以及在肿瘤中的作用，重点综述Caveolin-1在消化系统肿瘤的表达及其临床意义，并展望Caveolin-1在消化系统肿瘤中的应用前景。
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| 关 键 词： | 细胞窖蛋白-1 恶性肿瘤 消化系统肿瘤 |
Research advancement of Caveolin - 1 in digestive system tumors |
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| Zhang Kundong,Huang Chen,Qiu Zhengjun. Research advancement of Caveolin - 1 in digestive system tumors[J]. Journal of Modern Oncology, 2014, 0(1): 223-226 |
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| Authors: | Zhang Kundong Huang Chen Qiu Zhengjun |
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| Affiliation: | ( Department of General Surgery,Affiliated First People＇s Hospital, Shanghai Jiaotong University, Shanghai 200080, China.) |
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| Abstract: | The 21 -24kD membrane molecule, Caveolin - 1 is a major structural component of Caveolae. Caveolin - 1 is involved in diverse cellular processes ranging from cholesterol homeostasis and vesicular transport to signal transduction. Caveolin - 1 is also closely related to cancer pathogenesis, development and metastasis. This review aims to recommend the characteristics and functions of Caveolin - 1 and its roles in tumor development. Caveolin - 1 expression and clinical significance in digestive system tumors was reviewed mainly. Finally, the application prospect of Caveolin - 1 in digestive system tumors was viewed. |
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| Keywords: | Caveolin - 1 malignant tumor digestive system tumors |
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