KAI1 / CD82 和 MMP - 7 在多原发结直肠癌中的表达及临床意义简

目的：探讨KAI1／CD82和MMP-7的表达与多原发结直肠癌浸润、转移的关系。方法：应用免疫组织化学法检测KAI1／CD82和MMP-7在27例多原发结直肠癌及36例单发结直肠癌组织中的表达。结果：多原发结直肠癌组KAI1／CD82阳性表达率为76．7％，单发结直肠癌组KAI1／CD82阳性表达率为50．0％，两组有显著性差异（P〈0．05）。多原发结直肠癌组MMP-7阳性表达率为60．5％，单发结直肠癌组MMP-7阳性表达率为83．3％，两组有显著性差异（P〈0．05）。多原发结直肠癌组和单发结直肠癌组KAI1／CD82、MMP-7的阳性表达率在TNM分期、分化程度、浸润深度和有无淋巴结转移方面差异均有显著性意义。结论：KAI1／CD82、MMP-7的表达与结直肠癌的分期、分化程度、浸润深度和淋巴结转移有关。多原发结直肠癌的浸润、转移与KAI1／CD82和MMP-7的异常表达有关，它们可能协同作用，抑制肿瘤的侵袭和转移能力而促进多原发结直肠癌的发生。

Expression and clinical significance of KAI1/CD82 and MMP -7 in multiple primary colorectal carcinoma

Objective：To investigate the correlation of KAI1/CD82 and MMP -7 expression with the invasion and metastasis of multiple primary eoloreetal carcinoma（MPCC）. Methods ：The expressions of KAI1/CD82 and MMP- 7 were detected using immunohistoehemieal method in 27 cases of MPCC and 36 cases of solitary colorectal carcinoma （SCC）. Results：The positive expression rate of KAI1/CD82 was 76.7% in MPCC,which was significantly higher than that in SCC （50.0%, P 〈 0.05 ）. The positive expression rate of MMP- 7 was 60.5% in MPCC,which was significantly lower than that in SCC （ 83.3 % ,P 〈 0.05 ）. The positive expression rates of KAI1/CD82 and MMP - 7 bad a significant difference in TNM stage, differentiation, the depth of invasion and lymph node metastasis between MPCC and SCC. Conclusion：The positive expression rates of KAI1/CD82 and MMP -7 were related to TNM stage, differentiation,the depth of invasion and lymph node metastasis of eolorectal carcinoma. The abnormal expression of KAI1/ CD82 and MMP- 7 had a close relationship with the invasion and metastasis of MPCC. KAI1/CD82 and MMP -7 may cooperate with each other to inhibit the invasion and metastasis and induce the genesis of multiple primary colorectal carcinoma.