吸入性糖皮质激素对肺癌的化学预防作用及其机制简

研究证实COPD是肺癌的独立危险因素，吸烟为COPD和肺癌的共同危险因素，而炎症反应、氧化应激、表观遗传等在肺癌发生中也起着重要作用。动物模型及临床研究均证实吸入性糖皮质激素（ICS）具有肺癌化学预防作用，但其机制并不完全清楚。深入研究糖皮质激素参与调节肺癌发生的机制，可能有助于制定新的肺癌预防和治疗策略。本文就糖皮质激素在抗炎效应、调控遗传信息及细胞周期、诱导细胞凋亡等途径的作用机制作一综述，以期为深入探究糖皮质激素参与调节肺癌发生提供依据。

Inhaled corticosteroids on lung cancer chemoprevention and its mechanism

Chronic obstructive pulmonary disease（COPD） is an independent risk factor for lung cancer and smoking is a both common risk factor, Inflammation, oxidative stress, epigenetic also plays an important role. A growing number of animal models and clinical have confirmed inhaled corticosteroids （ICS） with lung cancer chemoprevention, but its mechanism is not fully understood. Depth study of the mechanisms involved in the regulation of lung cancer may contribute to the development of new prevention and treatment strategies. This review focuses on the anti - inflammatory effects, genetic information and cell cycle regulation and induce apoptosis pathway mechanism of glucocorticoids, in order to provide evidence that glucocorticoid involved in the regulation of lung cancer.