| 选择性 COX -2 抑制剂治疗胃癌的研究现状与展望简 |
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| 引用本文： | 刘小军,赵达,周永宁.选择性 COX -2 抑制剂治疗胃癌的研究现状与展望简[J].现代肿瘤医学,2014(1):238-240. |
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| 作者姓名： | 刘小军 赵达 周永宁 |
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| 作者单位： | 兰州大学第一医院,甘肃兰州730000 |
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| 基金项目： | 甘肃省卫生厅及兰州大学联合科研资助项目（编号：GWGL2010-19） |
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| 摘 要： | 环氧化酶-2催化花生四烯酸生成前列腺素的反应，在组织中呈诱导性表达，与肿瘤、炎症及疼痛等病理过程密切相关。选择性COX-2抑制剂塞来昔布可降低肿瘤组织E-钙黏素表达，降低癌细胞的侵}袭性，减少癌细胞的浸润与转移。塞来昔布治疗胃癌的临床前研究取得了丰硕的成果，本文将讨论近年来该领域的一些重要进展。
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| 关 键 词： | 环氧化酶-2 胃癌 塞来昔布 |
Current situation and future prospect of selective COX -2 inhibitor in the treatment of gastric cancer |
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| Liu Xiaojun,Zhao Da,Zhou Yongning.Current situation and future prospect of selective COX -2 inhibitor in the treatment of gastric cancer[J].Journal of Modern Oncology,2014(1):238-240. |
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| Authors: | Liu Xiaojun Zhao Da Zhou Yongning |
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| Institution: | ( The First Hospital of Lanzhou University, Gansu Lanzhou 730000, China.) |
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| Abstract: | Cyclooxygenase- 2 is an inducible isozyme of cyclooxygenase and catalyzes prostaglandin E2 formation related to pathological process, such as tumor, inflammation, and pain. Celecoxib, a selective COX -2 inhibitor, acts to reduce the risk of invasion and metastasis by lowering the expression of E - cadherin in tumor tissue. For recent years, great progress has been made for celecoxib in the treatment of gastric cancer in pre - clinical stage. Celecoxib was once applied as neo -adjuvant therapeutic agent for gastric cancer treatment by our group. Here, we discuss the progresses in this area. |
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| Keywords: | COX - 2 gastric cancer celecoxib |
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