精神分裂症患者脑皮层兴奋性的对照研究 |
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引用本文: | 高志勤,余海鹰,孙剑,崔雪莲,邱旭萍.精神分裂症患者脑皮层兴奋性的对照研究[J].中华行为医学与脑科学杂志,2008,17(5). |
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作者姓名: | 高志勤 余海鹰 孙剑 崔雪莲 邱旭萍 |
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作者单位: | 解放军第102医院,常州,213003 |
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摘 要: | 目的 了解精神分裂症患者的运动阈值(MT)与正常人的差异,以探讨精神分裂症患者的皮层兴奋性变化.方法 采用单脉冲经颅磁刺激(sTMS)检测均为右利手的48例精神分裂症患者和48例正常对照的MT值.结果 精神分裂症患者的MT值为左侧(47.01±9.14)高于右侧(44.59±10.54),差异有显著性(P<0.05);而正常对照的MT值为左侧(41.79±7.65)低于右侧(44.63±7.96),差异有非常显著性(P<0.01);精神分裂症患者左侧的MT值显著高于正常对照(P<0.05),而右侧的MT值与正常对照差异无显著性(P>0.05).结论 精神分裂症患者的皮层兴奋性与正常对照存在差异,具体表现为患者左、右两侧皮层兴奋性的不对称性与正常对照呈相反表现;精神分裂症患者左侧大脑皮层的兴奋性明显降低.
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关 键 词: | 精神分裂症 经颅磁刺激 运动阈值 皮层兴奋性 |
The research on cortical excitability in schizophrenic patients |
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Abstract: | Objective To investigate the difference of motor threshold(MT)between the schizophrenic patients and normal volunteers.and analyze the change of cortical excitability in patients.Methods 48 righthanded patients with schizophrenia and 48 right-handed healthy control subjects were used signal-pulse Transcranial Magnetic Stimulation(sTMS)to detect the MT.Resuits MT in left(47.01±9.14)was higher than right (44.59±10.54)in patients,and reverse in normal controls(t1=2.11,P1<0.05;t2=3.18,P 2<0.01).Compared with the controls,the left MT in schizophrenia was increased significantly(t=2.36,P<0.05),but no difference in right MT(t=0.10,P>0.05).Conclusion The interhemispheric asymmetries of brain motor cortical excitability in patients with schizophrenia disorder was opposite to the controls,and the left cortical excitability in patients had a evident decrease relative to normal subjects. |
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Keywords: | Schizophrenia Transcranial magnetic stimulation Motor threshold Cortical excitability |
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