复发性口腔溃疡5-羟色胺转运体启动子基因多态性研究

目的：探讨5-羟色胺转运体启动子区域（5-HTTLPR）基因多态性和复发性口腔溃疡之间是否存在关联性。方法：运用聚合酶链反应技术（PCR）检测分析T87例复发性口腔溃疡患者和96例健康人群的5-HTTLPR基因多态性。结果：两组5-HTTLPR基因型Short／Short（s／s）差异有显著性（x^2-6．423，P=0．044），提示s／s基因型携带者比L／L和S／L基因型的携带者患RAV的相对风险显著增高。结论：5-羟色胺转运蛋白启动子区的s／s纯合子基因型可能是RALL的易感基因之一。

The polymorphism of serotonin transporter gene in patients with recurrent oral ulcer

Objective：To Investigate whether there is association between the polymorphism of serotonin transporter gene-linked polymorphic region and recurrent oral ulcer. Methods：The polymorphism of serotonin transport protein gene-linked polymorphic region of 87 patients with recurrent oral ulcer and 96 normal people were detected with the polymerase chain reaction technique. Results ：The results showed that the short/short （S/S）genotype was significantly different between the patient group and control group （X2= 6. 423,P= 0. 044）. The S/S genotype was more susceptible to recurrent oral ulcers than L/L and S/L genotype. Conclusion：The S/S genotype in serotonin transport protein gene-linked polymorphic region may be one of the predisposing genes of recurrent oral ulcer.