食管癌细胞的雌激素和孕激素受体的研究

Estrogen and progesterone receptors in esophageal carcinoma cells

Distribution of estrogen and progesterone receptors (ER and PR) was studied in esophageal tissue (48 patients with esophageal carcinoma, 20 normal subjects and 12 fetuses) and Eca 109 cell line using enzyme-linking affinity immunohistochemistry method. In the meantime, plasma estradiol and progesterone levels were determined in 8 patients with esophageal carcinoma using radioimmunoassay method. The results showed that the positive rates of ER and PR in esophageal carcinoma were 43.75% (21/48) and 39.58% (19/48). Both ER and PR were positive in Eca 109 cell line whereas they were negative in the control groups. Sex and grade of cancer were the factors influencing the positive rates of ER and PR. It is indicated that carcinogenesis of esophageal carcinoma might be related to sex hormone metabolism. The measurement of ER and PR may be useful in clinical practice.