Attenuation of experimental retrograde amnesia through pretraining administration of a dissimilar amnestic agent |
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Authors: | Wesley J. Kasprow Todd R. Schachtman Mary Ann Balaz Ralph R. Miller |
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Affiliation: | Department of Psychology, State University of New York at Binghamton, Binghamton, NY 13901 USA |
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Abstract: | Experiment 1 found that pretraining administration of electroconvulsive shock (ECS) attenuated ECS-induced amnesia of one-trial passive avoidance training in rats. Similarly, pretraining injections of cycloheximide (CXM) attenuated the amnestic effects of CXM at training. Experiment 2 demonstrated the ability of pretraining ECS to attenuate CXM-induced amnesia and pretraining CXM to attenuate ECS-induced amnesia. These studies join others in observing comparable behavioral effects of ECS-like amnestic agents and antimetabolite-like amnestic agents despite their different means of primary action. Collectively, these studies support the view that the two families of amnestic agents produce amnesia through a common mechanism. |
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Keywords: | Amnesia Electroconvulsive shock Passive avoidance Cyclohexamide |
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