| 维生素D_3微囊的制备及含量测定 |
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| 引用本文： | 胡晓文,裴元英,陆国椿. 维生素D_3微囊的制备及含量测定[J]. 中国药房, 2008, 19(1): 41-43 |
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| 作者姓名： | 胡晓文 裴元英 陆国椿 |
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| 作者单位： | 1. 复旦大学附属肿瘤医院药剂科、复旦大学上海医学院肿瘤学系,上海市,200032
2. 复旦大学药学院药剂教研室,上海市,200032 |
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| 摘 要： | 目的:制备维生素D3微囊并建立其含量测定方法。方法:采用复凝聚法制备微囊;以高效液相色谱法测定维生素D3含量。结果:所制微囊粒径分布均匀,平均粒径(103.9±26.2)μm,包封率(90.8±2.68)%;维生素D3检测浓度的线性范围为0.1～1.0μg.mL-1(r=0.9993),平均回收率为98.65%,45min溶出度为75%以上。结论:该法成功制得维生素D3微囊,所建立的含量测定方法简便可行。
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| 关 键 词： | 维生素D_3微囊 高效液相色谱法 制备 含量测定 |
| 文章编号： | 1001-0408(2008)01-0041-03 |
| 修稿时间： | 2007-07-12 |
Preparation and Content Determination of Cholecalciferol Microcapsules |
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| HU Xiao-wen,PEI Yuan-ying,LU Guo-chun. Preparation and Content Determination of Cholecalciferol Microcapsules[J]. China Pharmacy, 2008, 19(1): 41-43 |
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| Authors: | HU Xiao-wen PEI Yuan-ying LU Guo-chun |
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| Affiliation: | HU Xiao-wen, LU Guo-chun,PEI Yuan-ying(Dept. of Pharmacy, Cancer Hospital of Fudan University/Dept. of Oncology, Shanghai Medical College of Fudan University, Shanghai 200032, China;Dept. of Pharmaceuticals, Pharmacy College, Fudan University, Shanghai 200032, China) |
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| Abstract: | OBJECTIVE： To prepare cholecalciferol （VitD3） microcapsules and establish a method for their quantitative determination. METHODS： Microcapsules were prepared by complex coacervation method and VitD3 content was determined by HPLC. RESULTS： The prepared microeapsules had well distributed particle size with average particle size of （103.9± 26.2） μm and encapsulation efficiency of （90.8± 2.68）%. The linear range of VitD3 was 0.1-1.0μg · mL^ -1（r = 0.999 3） with mean recovery rate of 98.65% and a dissolution rate of above 75% at 45 min. CONCLUSION： VitD3 microcapsules was successfully prepared by the established method, and the established content determination method was proved to be simple and feasible. |
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| Keywords: | VitD_3 microcapsules HPLC Preparation Content determination |
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