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| 轻度认知功能障碍患者认知功能与内颞叶各结构体积的关系 | |
| 引用本文： | 刘洁琼,张新卿,高勇安,汤哲,陈彪,刘东惠,秦晓明.轻度认知功能障碍患者认知功能与内颞叶各结构体积的关系[J].临床神经病学杂志,2009,22(1). |
| 作者姓名： | 刘洁琼 张新卿 高勇安 汤哲 陈彪 刘东惠 秦晓明 |
| 作者单位： | 1. 首都医科大学宣武医院神经内科,北京,100053 2. 首都医科大学宣武医院放射科,北京,100053 3. 首都医科大学宣武医院社会医学部,北京,100053 4. 清华大学附属第一医院神经内科 |
| 基金项目： | 北京市科技计划资助项目(Z0005187040191) |
| 摘 要： | 目的研究轻度认知功能障碍(MCI)患者认知功能与内颞叶各结构体积的关系。方法17例MCI患者和21名正常老年人分别接受临床评估、神经心理检查和头颅MR扫描,在重建的图像上测量内颞叶各结构的体积,并行标准化处理;对神经心理学指标与内颞叶结构MR指标进行相关性分析。结果MCI组和正常老年组的神经心理量表除物体记忆测验(FOM)外,其余各项得分差异均无统计学意义;两组MR内颞叶结构体积比较差异亦均无统计学意义(均P>0.05)。在MCI组中,短时记忆、逻辑记忆(LM)得分与内嗅皮质体积呈正相关(r=0.484、0.529,均P<0.05),无意义图形再认(MGR)、FOM得分与海马体积呈正相关(r=0.502、0.659,均P<0.05),短时记忆、MGR得分与左侧杏仁核体积呈正相关(r=0.557、0.644,均P<0.05);正常老年组短时记忆、LM和数字广度(DS)测验得分与双侧内嗅皮质体积呈负相关(r=-0.448、-0.718,均P<0.05),注意力、计算力与右侧杏仁核、双侧海马体积均呈负相关(r=-0.451、-0.553,均P<0.05)。结论MCI患者的认知功能与内颞叶各结构体积有关;不同的认知功... |
| 关 键 词： | 轻度认知功能障碍 认知功能 磁共振成像 |
Correlation between cognitive functions and each structured volumes of medial temporal lobe in patients with mild cognitive impairment |
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| LIU Jie-qiong,ZHANG Xin-qing,GAO Yong-an,et al..Correlation between cognitive functions and each structured volumes of medial temporal lobe in patients with mild cognitive impairment[J].Journal of Clinical Neurology,2009,22(1). | |
| Authors: | LIU Jie-qiong ZHANG Xin-qing GAO Yong-an |
| Institution: | LIU Jie-qiong,ZHANG Xin-qing,GAO Yong-an,et al. Department of Neurology,Xuanwu Hospital of Capital University of Medical Sciences,Beijing 100053,China |
| Abstract: | Objective To study the correlation between cognitive functions and each structured volumes of medial temporal lobe in patients with mild cognitive impairment(MCI).Methods 17 patients with MCI and 21 normal elderly were examined by clinical evaluation, cognitive function and scanned by MRI. The each structured volumes of medial temporal lobe were measured on a serial reconstructed MR images. Relationship between cognitive functions and each structured volumes of medial temporal lobe was analyzed.Results Ther... |
| Keywords: | mild cognitive impairment cognitive functions MRI |
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