阻塞性睡眠呼吸暂停低通气综合征患者健康相关生命质量与多导睡眠监测结果相关性

目的评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者健康相关生命质量(HRQoL),并研究其与多导睡眠监测(PSG)结果、过度白天嗜睡的相关性,寻找影响OSAHS患者HRQoL的因素。方法对64例OSAHS患者和50例正常对照使用健康结局问卷(SF-36)和Epworth嗜睡问卷(ESS)评估并比较其HRQoL。研究OSAHS患者SF-36评分与PSG监测结果、ESS评分和生理指标之间的相关性,分析造成其HRQoL变化的因素。结果OSAHS患者与正常对照相比,SF-36中4个维度及总分显著下降,整体处于白天过度嗜睡状态;OSAHS患者ESS评分与SF-36中6个维度及总分呈显著负相关;SF-36总分、ESS评分与觉醒指数呈显著负相关;SF-36总分与血氧低于90%占睡眠比例(SaO290%)呈显著负相关;ESS是OSAHS患者HRQoL的独立预测因素,能解释SF-36总分变异的26.9%。结论OSAHS患者健康相关生命质量有明显的损害。过度白天嗜睡、夜间严重持续的低氧血症和睡眠结构的破坏可能是引起HRQoL损害的主要原因。

Correlation between the health-related results in patients with obstructive quality of life and polysomnography sleep apnea hypopnea syndrome

Objectives To explore the health-related quality of life(HRQoL) in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and its relationship with the polysomnogrphy(PSG) results and with excessive daytime sleepiness.Methods 64 patients with OSAHS and 50 control subjects were measured for HRQoL using the Medical Outcomes Study Short-Form 36 survey(SF-36) and Epworth Sleepiness Scale(ESS).The differences were examined by an independent-sample t test.The associations between the SF-36 and PSG results,ESS and other physical parameters were examined by simple linear correlation analysis and multiple stepwise multiple regression analysis.Results Excessive daytime sleepiness was found in OSAHS patients.4 of 8 domains and the total scores on the SF-36 of patients with OSAHS were significantly lower than those in the controls.In OSAHS patients,6 of 8 domains and the total scores on the SF-36 patients were significantly correlated with the ESS scores.ESS scores and the total scores on SF-36 were significantly correlated with arousal indexes on PSG.The total scores on SF-36 were significantly correlated with the SaO2<90% sleep percentages on PSG.ESS scores served as an independent factor for predicting the total scores on SF-36 which accounted for 26.9% of the total variance.Conclusions The HRQoL of patients with OSAHS decreases compared with the controls,and excessive daytime sleepiness,nocturnal durative hypoxemia,and sleep disruption seem toplay important roles.