帕罗西汀治疗肠易激综合征患者的情绪障碍及腹部症状

探讨选择性５－羟色胺现摄取抑制剂（ＳＳＲＩ）帕罗西汀治疗肠易激综合征（ＩＢＳ）的疗效，以及ＩＢＳ患者精神症状与腹部症状的关系。方法：３６例有精神障碍表现的ＩＢＳ患者服用幅罗西汀治疗８周，治疗前后分别对患者行汉密尔顿抑郁量表（ＨＡＭＤ）、汉密尔顿焦虑量表（ＨＡＭＡ）和胃肠道症状计分标准（ＧＳＲＳ）评分并分析３种 发的相关性。结果：ＩＢＳ患者服用帕罗西汀治疗前后的ＨＡＭＤ、ＨＡＭＡ和ＧＳＲＳ评分存在显

Paroxetine in the Treatment of Irritable Bowel Syndrome

Background/Aims: To investigate the effect of selective serotonin reuptake inhibitor (SSRI) on irritable bowel syndrome (IBS) and the relevance of psychological factors and abdominal symptoms in IBS patients. Methods: SSRI paroxetine was used for a period of 8 weeks. The psychological status of 36 IBS patients was analyzed with Hamilton depression (HAMD), Hamilton anxiety (HAMA), and subjective symptoms with gastrointestinal symptoms rating scale (GSRS) before and after the treatment. Results: The scores of HAMD, HAMA and GSRS of IBS patients improved significantly after the treatment (P< 0.001), psychological and abdominal symptoms were also improved. There was a positive correlation among HAMD/HAMA and GSRS. Conclusions: Serotonin may play an important role in the development of psychological and abdominal symptoms of IBS, and paroxetine is effective in its treatment.