高选性迷走神经切断术对胃粘膜血流量的影响

对12只健康狗在高选性迷走神经切断术前后的胃粘膜血流量及酸分泌进行了2个月的研究。术前,经胃泌素刺激,胃体粘膜血流量增加45％左右;术后,血流升高幅度明显低于术前,仅20％左右。对胃酸分泌的影响与此相似。本实验通过内窥镜,应用了改良氢气排出法。此法无毒无损伤,可反复在同一动物测定,是一种较好的胃粘膜血流量测定方法。

THE EFFECT OF HIGHLY SELECTIVE VAGOTOMY ON GASTRIC MUCOSAL BLOOD FLOW

Gastric mucosal blood flow (GMBF) and acid secretion were studied before and after highly selective vagotomy (HSV) on 12 health dogs for two months. Before HSV the blood flow increased about 45% in the pentagastrin stimulated corpus, whereas there was no significat change in antrum.Though HSV had no significant influence on resting GMBF, it did influence the mucosal blood flow of corpus during pentagastrin infusion. After HSV the increase in pentagastrin-stimulated corpus mucosal blood flow was around 20%. Which was significantly diminished compared with the increase observed before operation. The changes of acid secretion were similar to those of GMBF.Through the endoscope, modified hydrogen gas clearance method was used in the study. This method is noninvasive, nontoxic, and can be repeated on the same animal at specific intervals without being influenced by changes in secretory activity of the gastric mucosa. It seems to be a good method for measuring GMBF.