非堵塞性输精管滤过装置节育术效果的临床研究

报告125例输精管滤过装置(IVD)节育术与125例钳穿法输精管结扎术临床比较研究一年观察结果:两组随访率分别为96.0％(IVD组)和94.40％(结扎组);节育有效率分别为99.2％和100％(P>0.05),精子消失率分别为68.3％和99.2％(P<0.001)。IVD组术后半年和一年分别有91.57％和79.17％的研究对象的精浆测出中性α—糖苷酶活性,证明IVD组术后大部分受试者仍有附睾液通过,与结扎组术后半年的4.48％和一年的4.24％比较,有非常显著的差异(P<0.001)。IVD组术后并发症有感染1例,而结扎组有感染、附睾淤积症、性功能障碍各1例。并发症总发生率为0.83％(IVD组)和2.54％(结扎组),无显著差异。术后附睾肿大和近睾端输精管增粗现象,IVD组的发生率为3.3％和11.7％,结扎组的发生率为60.2％和62.7％,两组间有非常显著的差异(P<0.001)。IVD组术后血清精子凝集抗体阳性率明显低于结扎组。结果表明:IVD置入输精管腔后节育效果可靠且能减轻附睾淤积的发生,有可能成为一种较理想的非堵塞性输精管内节育器。

Clinical Study of Contraception Efficacy of the Non-occlusive Intra - Vas Device.

One hundred and twenty-five volunteers implanted intra-vas device (IVD) to compare to that of 125 volunteers undergone no-scalpel vasectomy were recruited into the study and followed for 1 year. The results showed that the efficacy rates of contraception in both the IVD group and ve-sectomy group were. 99. 20% and 100% while rates of sperm disappearance in ejaculates in the two geoups were 68. 3% and 99. 2% , respectively, 91. 57% and 79. 17% of volunteers in the IVD group were found to have α-glucosidase activity in their seminal plasma at 6 and 12 months after operation, suggesting that epididymal fluid could pass through the IVD, There was significant difference between the two groups in α-glucosidase activity in their seminal plasma and epdidymis sweeling and dilaon of proximal vas deferens, There was not any significant difference between the two groups in complication rate. In addition, positive rate of serum antisperm antibodies in IVD group was lower than that of noscalpel vesectomy group. Our results indicate that implanted IVD, provides a favorable approach to prevent from epididymalstasis while has the same contraception efficacy as no-scalple vesectomy.