管状和柱状磷酸三钙陶瓷人工骨修复长骨大段骨缺损的对比研究

为研制理想的、能较快修复长骨大段骨缺损的陶瓷人工骨 ,我们将管状磷酸三钙 ( TTCP)和柱状磷酸三钙 ( CTCP)陶瓷人工骨分别植入兔桡骨于 1cm缺损处。术后 4、12周时取材 ,作大体组织形态学、新骨形成定量观察及抗折强度测试。术后 4、12周时 TTCP内新骨形成量明显多于 CTCP,术后 12周时 ,植入材料与宿主骨结合紧密 ,TTCP的降解速度快于 CTCP,抗折强度前者明显高于后者 ( P<0 .0 1)。研究结果表明 ,TTCP比 CTCP设计更合理 ,能更快促进长骨大段骨缺损的修复 ,是一种较理想的人工骨材料

Comparative Study on Using TTCP and CTCP Ceramic Artificial Bone for Repairing Segment Defect of Long Bone

To develop ideal ceramic artificial bone for accelerating the process of repairing segment defect of long bone, tubing tricalcium phosphate (TTCP) and column tricalcium phosphate (CTCP) ceramic artificial bones were implanted separately into radial defects of 1 cm in adult rabbits.Specimens were taken in 4 and 12 weeks. The samples were examined by gross histomorphological observation, quantitative measurement of new bone formation and bending strength. The amount of new bone formation in TTCP was more than that in CTCP at 4 and 12 weeks postoperatively. At 12 weeks after operation, the grafted materials were bonded closely with host bone. The degradation rate of TTCP was faster than that of CTCP, and the bending strength of TTCP was stronger than that of CTCP( P<0 01) . The results showed that the design of TTCP is relatively rational and TTCP could accelerate the repair of segment defect of long bone more rapidly than CTCP. TTCP is an ideal artificial bone material.