放射治疗对NSCLC患者外周血Treg细胞水平的影响

目的 研究放射治疗对NSCLC患者外周血Treg细胞水平的影响。方法 分析50例NSCLC患者放射治疗前后外周血CD4⁺ CD25⁺ Foxp3⁺ Treg/CD4⁺比值的变化，及其与临床特征的关系。结果 NSCLC患者放射治疗后CD4⁺ CD25⁺ Foxp3⁺ Treg细胞占CD4⁺ T细胞的比例显著降低，与肿瘤直径、肿瘤分期及分化程度有关。结论 CD4⁺ CD25⁺ Foxp3⁺ Treg细胞水平在NSCLC放射治疗过程中变化显著，可能成为NSCLC预后的重要预测指标。

Effect of radiation therapy on Treg cells in peripheral blood of NSCLC patients

Objective To study the effect of radiation therapy on peripheral blood Treg cells in NSCLC patients. Methods To analyze the changes of CD4⁺ CD25⁺ Foxp3⁺ Treg/CD4⁺ cells ratio in peripheral blood of 50 NSCLC patients before and after radiation therapy, and their relationship with clinical characteristics. Results The proportion of CD4⁺ CD25⁺ Foxp3⁺ Treg cells in CD4⁺ T cells was significantly decreased after radiotherapy in NSCLC patients, which was related to tumor diameter, tumor stage and differentiation. Conclusion The level of CD4⁺ CD25⁺ Foxp3⁺ Treg cells significantly changed during NSCLC radiation therapy, which may be an important prognostic indicator of NSCLC.