Disturbed hypothalamic-pituitary axis in idiopathic recurring hypersomnia syndrome |
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| Authors: | J.-M. Ferná bdez,I. Lara,L. Gila,A. O''Neill,J. Tovar,A. Gimeno |
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| Affiliation: | Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain. |
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| Abstract: | Disturbed function of the hypothalamic-pituitary axis at adrenal and thyroid levels was found during an episode of hypersomnia in the idiopathic recurring hypersomnia syndrome. These endocrinological abnormalities, abolished ACTH and cortisol responses to insulin-induced hypoglycemia and absent TSH response to TRH, normalised thereafter in the symptom-free interval. These data support the hypothesis that Kleine-Levin syndrome is related to an intermittent hypothalamic dysfunction. |
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| Keywords: | idiopathic recurring hypersomnia syndrome Kleine-levin syndrome hypothalamic-pituitary axis |
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