Intravenous Lidocaine for the Emergency Department Treatment of Acute Radicular Low Back Pain,a Randomized Controlled Trial |
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Authors: | David A. Tanen Mai Shimada D. Chris Danish Frank Dos Santos Martin Makela Robert H. Riffenburgh |
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Affiliation: | ∗ Department of Emergency Medicine, Naval Medical Center San Diego, San Diego, California;† University of Tokyo Medical School, Tokyo, Japan;‡ Department of Emergency Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia;§ Division of Emergency Medicine, University of Washington, Seattle, Washington;|| Clinical Investigations Department, Naval Medical Center San Diego, San Diego, California |
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Abstract: | BackgroundAcute radicular back pain is a frequent complaint of patients presenting to the Emergency Department.Study ObjectiveDetermine the efficacy of intravenous lidocaine when compared to ketorolac for the treatment of acute radicular low back pain.MethodsRandomized double-blind study of 41 patients aged 18–55 years presenting with acute radicular low back pain. Patients were randomized to receive either 100 mg lidocaine or 30 mg ketorolac intravenously over 2 min. A 100-mm visual analog scale (VAS) was used to assess pain at Time 0 (baseline), and 20, 40, and 60 minutes. Changes in [median] VAS scores were compared over time (within groups) by the signed-rank test and between groups by the rank-sum test. A 5-point Pain Relief Scale (PRS) was administered at the conclusion of the study (60 min) and again at 1 week by telephone follow-up; [median] scores were compared between groups by rank-sum.ResultsForty-four patients were recruited; 41 completed the study (21 lidocaine, 20 ketorolac). Initial VAS scores were not significantly different between the lidocaine and ketorolac groups (83; 95% confidence interval [CI] 74–98 vs. 79; 95% CI 64–94; p = 0.278). Median VAS scores from baseline to 60 min significantly declined in both groups (lidocaine [8; 95% CI 0–23; p = 0.003]; ketorolac [14; 95% CI 0–28; p = 0.007]), with no significant difference in the degree of reduction between groups (p = 0.835). Rescue medication was required by 67% receiving lidocaine, compared to 50% receiving ketorolac. No significant change in PRS between groups was found at the conclusion or at the follow-up.ConclusionIntravenous lidocaine failed to clinically alleviate the pain associated with acute radicular low back pain. |
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Keywords: | lidocaine ketorolac radicular pain |
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