133 例恶性淋巴瘤骨髓细胞学分析

目的:探讨恶性淋巴瘤骨髓浸润的临床特点。方法:回顾性分析133 例经病理确诊的恶性淋巴瘤病例，分析其骨髓浸润情况。结果:133 例恶性淋巴瘤患者中骨髓受累率为21.8%（29/133）；在骨髓受累的病例中，淋巴肉瘤性白血病、骨髓侵犯、淋巴瘤细胞比例未达5% 的病例分别占31.0%（9/29）、55.2%（16/29）和13.8%（4/29）。 在29例骨髓受累病例中，B 细胞淋巴瘤占55.2%（16/29），T/NK细胞淋巴瘤占41.4%（12/29），霍奇金病占3.4%（1/29）。 T/NK细胞淋巴瘤的骨髓受累率为37.5%（12/32），比B 细胞淋巴瘤要高18.2%（16/88），两组具有统计学差异。结论:恶性淋巴瘤骨髓浸润比例高，不同的病理学类型骨髓受累的风险不一，总体而言T 细胞淋巴瘤的骨髓浸润率更高，而且以淋巴肉瘤性白血病多见，骨髓细胞学检查对恶性淋巴瘤的正确分期、治疗方案的选择和预后判断有重要的意义。 

Bone Marrow Cytological Analysis of Malignant Lymphoma: A Retrospective Study of 133 Cases

Objective:To investigate the clinical features of bone marrow infiltration in patients with malignant lympho -ma. Methods:Atotal of 133 patients with pathologically confirmed malignant lymphoma were collected and the characteris-tics of the bone marrow infiltration were analyzed. Results: The rate of bone marrow involvement was 21.8% (29/133 ). In 29 cases with bone marrow involvement, the ratio of patients with lymphosarcoma leukemia, bone marrow infiltration and lym-phoma cells less than 5% was31.0% (9/29), 55.2% (16/29) and 13.8% (4/29), respectively. In these 29cases, B-cell lym -phoma accounted for 55.2% (16/29), T / NK cell lymphoma accounted for 41.4% (12/29) and Hodgkin's disease accounted for 3.4% (1/29). The rate of bone marrow involvement in T / NK cell lymphoma was 37.5% (12/32), higher than that in B-cell lymphoma ( 18.2%,16/88). The difference between the two groups was statistically significant. Conclusion:There is a high proportion of bone marrow involvement in patients with malignant lymphoma, and distinct pathological types have different risks of bone marrow involvement. Overall, there is a higher rate of bone marrow involvement in T-cell lymphoma, mainly in lymphosarcoma leukemia. Bone marrow cytology is of great significance for patients with malignant lymphoma with regards to the correct staging, treatment options and prognosis.