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| 缺氧诱导因子1α在妊高征和正常妊娠胎盘组织中的差异表达 | |
| 引用本文： | 吴维光,姚元庆,李东红,于月成,范小斌,张伟.缺氧诱导因子1α在妊高征和正常妊娠胎盘组织中的差异表达[J].细胞与分子免疫学杂志,2005,21(3):362-364. |
| 作者姓名： | 吴维光 姚元庆 李东红 于月成 范小斌 张伟 |
| 作者单位： | 1. 第四军医大学,唐者医院妇产科,,陕西,西安,710038 2. 第四军医大学,西京医院妇产科,陕西,西安,710032 3. 第四军医大学,唐都医院病理科,陕西,西安,710038 |
| 摘 要： | 目的:探讨缺氧诱导因子1α(HIF-1α)蛋白及其mRNA在妊高征和正常妊娠胎盘组织中的表达的差异。方法:应用Westernblot检测10例妊高征和10例年龄匹配的正常妊娠的胎盘组织中HIF-1α蛋白表达的水平;应用实时定量PCR,检测两种组织中HIF-1αmRNA表达的水平。结果:与正常妊娠胎盘组织相比较,妊高征胎盘组织中HIF-1α蛋白和mRNA的表达水平明显增加(P<0.05)。结论:HIF-1α在妊高征胎盘组织中表达增高,可能与妊高征的病因及病理生理有关。 |
| 关 键 词： | 妊高征 胎盘 HIF-1α |
| 文章编号： | 1007-8738(2005)03-0362-03 |
| 修稿时间： | 2004年6月16日 |
The differential expression of hypoxia-inducible factor-1α in placenta tissues from pregnancy induced hypertension and normal pregnancy |
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| WU Wei-Guang,YAO Yuan-Qing,LI Dong-Hong,YU Yue-Cheng,FAN Xiao-Bin,ZHANG Wei.The differential expression of hypoxia-inducible factor-1α in placenta tissues from pregnancy induced hypertension and normal pregnancy[J].Journal of Cellular and Molecular Immunology,2005,21(3):362-364. | |
| Authors: | WU Wei-Guang YAO Yuan-Qing LI Dong-Hong YU Yue-Cheng FAN Xiao-Bin ZHANG Wei |
| Institution: | Department of Obstetrics and Gynecology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. |
| Abstract: | AIM: To explore the differential expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in placenta tissues from pregnancy induced hypertension and normal pregnancy. METHODS: The expression of HIF-1alpha protein and mRNA was detected by Western blot and real-time PCR, respectively. RESULTS: As compared with the expression levels of HIF-1alpha protein and mRNA in placenta tissues from normal pregnancy, those from pregnancy induced hypertension increased notably (P<0.05). CONCLUSION: The high expression of HIF-1alpha in the placenta tissues pregnancy induced may relate with pathogenesis and pathophysiological process of hypertension. |
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