青少年幽门螺杆菌相关性缺铁性贫血临床研究

目的:探讨幽门螺杆菌(helicobacter phyori,Hp)感染与青少年缺铁性贫血(iron deficiency anemia,IDA)的关系。方法:选择伴慢性胃炎的IDA患者82例(观察组)和慢性胃炎无贫血患者60例(对照组),均行快速尿素酶试验,内镜下组织病理检查;观察组Hp阳性患者随机分为A、B、C3组,A组给予硫酸亚铁和抗Hp治疗,B组给予硫酸亚铁和安慰剂治疗,C组给予抗Hp治疗;观察治疗前后患者的血红蛋白(Hb)、红细胞计数(RBC)、平均红细胞容积(MCV)、网织红细胞(Ret)、血清铁(SI)、血清铁蛋白(SF)等血液学指标的变化。结果:观察组82例中70例Hp阳性,对照组60例中43例Hp阳性,两组间差异有显著意义(P<0.01);观察组中A、C组与B组比较,治疗前后血液学指标改变及疗效差异有显著意义(P<0.05)。结论:Hp感染与青少年IDA有一定相关性,抗Hp加铁剂是治疗Hp感染相关性缺铁性贫血的有效方法。

Clinical Study on Iron Deficiency Anemia Related with Heficobacter Phyori Infection Teenagers

Objective:To investigate the relationship between helicobacter pylori (H. pylori) infection and iron deficiency anemia( IDA) for teenagers. Methods:Rapid urease test and gastroscopy were used to examin 82 teenagers patients of IDA in association with chronic gastritis(study group), 60 patients only with chronic gastritis (control group). All of the patients were 10～18 years old. The study group (H. pylori positive) was randomly divided into three groups (A,B,C) again. Group A (including 30 cases ) was given ferrous sulfate and eradication of H. pylori infection, group B (20 cases ) given ferrous sulfate and placebo, group C (20 cases ) given eradication of H. pylori infection. Around the therapy, hemoglobin (Hb), red blood cell (RBC), mean corpuscular volum (MCV), reticulocyte (Ret), serum iron (SI) and serum ferritin (SF) were measured on the patients of the study group. Results: The cases with Hp positive was 70 in the study group and 43 in control group , the two groups have outstanding differences(P<0.01). The differences in change of hematological examination and curative effect were obvious in patients of group A, C and of group B. Conclusions: There is certain correlation between H. pylori infection and IDA. It is effective for teenagers with IDA in association with H. pylori infection to give ferrous sulfate and eradication of H. pylori infection.