唾液尿素氮、肌酐、尿酸浓度测定及临床意义

目的 探讨唾液中尿素氮、肌酐及尿酸浓度检测及临床意义。方法 将2005年10月～2006年2月本院住院病人80例和健康成人35例，使用全自动生化分析仪分别检测唾液和血清中的尿素氮、肌酐及尿酸浓度。结果 健康对照组唾液与血清尿素氮、肌酐及尿酸相关系数分别是0.613,0.715,0.748;慢性肾功能不全肾病组唾液与血清肌酐相关系数r（Cr）为0.561，随着血清肌酐浓度的升高，其与唾液肌酐的相关性亦越高；慢性肾功能不全肾病组唾液尿酸与血清UA含量相关系数最高，r（UA）为0.234，唾液中尿酸浓度随着血清尿酸浓度的升高而增加。结论 唾液尿素氮、肌酐及尿酸的检测可用于判断肾脏病患者肾功能的损害程度。

Clinical Significance of Determination for BUN,Cr,Ua in Saliva

Objective To discuss the clinical significance of determination for BUN,Cr,UA in saliva.Methods The Olympus AU600 automatic biochemical analytic system to determine the concentration of BUN,Cr,UA in saliva and serum of 80 patients from October 2005 to February 2006 and 35 healthy adults.Results The relative coefficients of BUN,Cr,UA in saliva and serum are 0.613,0.715,0.748 respectively;The relative coefficients of chronic renal functional failure between saliva and serum is 0.561,with increasing of Cr in serum,the relationship of Cr between serum and saliva is closer;UA in saliva and serum are related unconspicuously,the relationship of chronic renal functional failure between saliva and serum is the highest(r=0.234),the relationship is closer with increasing of UA in serum.Conclusions The determination of BUN,Cr,UA in saliva can be used to evaluate renal function.