小剂量阿司匹林、银杏达莫注射液联合用药对急性脑梗死患者血小板功能的影响

目的观察小剂量阿司匹林与银杏达莫注射液联合应用对急性脑梗死患者血小板数目、体积及功能的影响,临床疗效和安全性。方法将本院同期住院的急性脑梗死患者随机分为对照组与治疗组。2组患者均给予内科常规治疗,并于发病后24~48h给予肠溶阿司匹林;治疗组在此基础上加用银杏达莫注射液。2组患者均不再应用其他抗血小板聚集的药物。用药观察治疗28d,分别于治疗前、治疗后第14天、第28天测定血小板数目、体积、黏附率及聚集率,并进行神经功能缺损积分评定,判定临床疗效及安全性。结果2组治疗后第14天、第28天时血小板数目均高于治疗前;体积、黏附率及聚集率均明显低于用药前,经统计学处理有显著性差异(P均<0.05),2组之间比较经统计学处理有显著性差异(P<0.01)。治疗第28天治疗组总有效率为92.78%,显效率为67.22%;对照组总有效率为81.67%,显效率为50.56%,2组总有效率及显效率比较均有显著性差异(P均<0.05)。结论小剂量阿司匹林与银杏达莫注射液联合应用治疗急性脑梗死能明显降低患者的血小板聚集率及黏附性;提高临床疗效,且无明显不良反应。

Influence of low-dose Aspirin combined with Yinxingdamo injection on platelet function of patients with acute cerebral infarction

Objective It is to observe the influence, clinical curative effect and safety of low-dose Aspirin combined with Yinxingdamo injection on platelet number, volume and function of the patients with acute cerebral infarction. Methods 360 patients with acute cerebral infarction were randomly divided into control group and treatment group. Every patient was given normal medical therapy and aspirin after 24 to 48 hours. Every patient in treatment group was given Yinxingdamo injection. They were forbidden to take any other antiplatelet drugs. Every patient was treated and observed 28 days. The number, volume, adhesive rate and aggregative rate of platelet were measured and the clinical curative effect and safety were evaluated with defect integral of nerve function before treatment, the 14th day and the 28th day after treatment. Results The number of platelet at the 14th day and the 28th day after treatment was higher than that before treatment. The volume, adhesive rate and aggregative rate of platelet were obviously lower at the 14th day and the 28th day after treatment than that before treatment (P<0.05). There was significant difference between the two groups (P<0.01). At the 28th day after treatment the total effective rate and excellence rate of the treatment group were 92.78% and 67.22%, at the same time the total effective rate and excellence rate of the control group were 81.67% and 50.56%. There was significant difference between the two groups (P<0.05). Conclution Low-dose Aspirin combined with Yinxingdamo injection can obviously debase the volume, adhesive rate and aggregative rate of platelet and heighten the clinical curative effect, and it has no obvious untoward reaction in treating acute cerebral infarction.