Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan |
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| Authors: | Ryoichi Hamasuna Mitsuru Yasuda Kiyohito Ishikawa Shinya Uehara Satoshi Takahashi Hiroshi Hayami Shingo Yamamoto Tetsuro Matsumoto Shinichi Minamitani Akira Watanabe Aikichi Iwamoto Kyoichi Totsuka Junichi Kadota Keisuke Sunakawa Junko Sato Hideaki Hanaki Taiji Tsukamoto Hiroshi Kiyota Masaru Yoshioka |
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| Affiliation: | Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, 807-8555, Kitakyuhsu, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, Graduate School of Medicine, Gifu University, Gifu, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, School of Medicine, Fujita Health University, Nagoya, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Blood Purification Center, Kagoshima University Hospital, Kagoshima, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;Department of Urology, Hyogo College of Medicine, Nishinomiya, Japan;Urogenital Sub-committee and the Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan;The Surveillance Committee of JSC, JAID and JSCM, Tokyo, Japan;The Kitasato Institute, Tokyo, Japan;Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Japan;Department of Urology, The Jikei University Katsushika Medical Center, Tokyo, Japan;Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan |
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| Abstract: | Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance. The urethral discharge was collected from male patients with urethritis at 51 medical facilities from April 2009 to October 2010. Of the 156 specimens, 83 N. gonorrhoeae strains were tested for susceptibility to 18 antimicrobial agents. The prevalence of β-lactamase-producing strains and chromosomally mediated resistant strains were 7.2 % and 16.5 %, respectively. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) of ceftriaxone for 7 strains (8.4 %) was 0.125 μg/ml. One strain was resistant to cefixime (MIC 0.5 μg/ml). The MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin, and tosufloxacin, showed a bimodal distribution. The MIC of sitafloxacin was lower than those of the three fluoroquinolones listed here, and it was found that the antimicrobial activity of sitafloxacin was stronger than that of the fluoroquinolones. The MIC of azithromycin in 2 strains was 2 μg/ml, but no high-level resistance to macrolides was detected. |
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| Keywords: | Neisseria gonorrhoeae Nationwide surveillance Antimicrobial susceptibilities Japan |
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