Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients |
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| Authors: | Amal S El-Shal Nader M Aly Sahar M Abdel Galil Mohamed A Moustafa Wael A Kandel |
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| Institution: | 1. Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt;2. Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt;3. Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt;4. Orthopedic Surgery Department, Faculty of Medicine, Benha University, Benha, Egypt |
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| Abstract: | ObjectiveTo investigate whether miRNA-499 (rs3746444) and miRNA-146a (rs2910164) genes polymorphisms are independent factors for rheumatoid arthritis (RA) in Egyptians, and whether they influence disease severity and activity.MethodsTwo hundred and seventeen RA patients and 245 healthy controls were enrolled in this study. Polymorphisms of miRNA-146a and miRNA-499 genes were detected using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).ResultsThe miRNA-499 CT genotype was an independent factor of RA. The miRNA-499 CT, CC genotypes and C allele frequencies were significantly increased in erosive RA group. Moreover, the heterozygote CT had more severe and more active form of the disease compared with homozygote CC or TT. However, we did not find any significant association of miRNA-146a polymorphism with RA risk, severity, and activity.ConclusionThe miRNA-499 polymorphism is an independent factor of RA, and influences disease severity and activity. |
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| Keywords: | Rheumatoid arthritis MicroRNA Polymorphism Egyptian population |
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