Two cases of Takayasu's arteritis occurring under anti-TNF therapy |
| |
Authors: | Nicola Mariani Alexander So Bérengère Aubry-Rozier |
| |
Institution: | Service de rhumatologie et centre des maladies osseuses, département de l’appareil locomoteur, hôpital orthopédique, 4, avenue Pierre-Decker, 1011 Lausanne, Switzerland |
| |
Abstract: | Takayasu's arteritis is a granulomatous, large vessel vasculitis that affects the aorta, its major branches and the pulmonary arteries. Compelling evidence exists to support the notion that Takayasu's arteritis is a T-cell mediated process and that tumor necrosis factor alpha (TNFa) is an important factor in the pathogenesis of this disease. Moreover, encouraging results from recent studies support the use of anti-TNFa therapy for relapsing or resistant cases of Takayasu's arteritis. Here, however, we describe the case of two patients: one with seropositive rheumatoid arthritis, the other with HLA-B27 negative spondylarthropathy, who developed Takayasu's arteritis during treatment with TNFa inhibitors (adalimumab and golimumab respectively). This is the first report of Takayasu's arteritis in rheumatic patients under TNFa blocking agents which suggests the presence of different pathogenetic mechanism in a subgroup of patients with Takayasu's arteritis, as well as a potential role of TNFa blockers as triggers of this disease in some cases. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|