| 外泌体miRNA在缺血性心脏病中的作用机制及靶向治疗前景 |
| |
| 引用本文： | 于晓朴,边云飞,庞有成,郭旭男,王东英.外泌体miRNA在缺血性心脏病中的作用机制及靶向治疗前景[J].中国动脉硬化杂志,2021,29(2):171-178. |
| |
| 作者姓名： | 于晓朴 边云飞 庞有成 郭旭男 王东英 |
| |
| 作者单位： | 山西医科大学;山西医科大学第二医院心内科 |
| |
| 基金项目： | 国家自然科学基金面上项目(82070472)。 |
| |
| 摘 要： | 缺血性心脏病(IHD)的发生是从多种潜在危险因素到临床显性疾病的多步骤链式进程.利用外泌体作为IHD的治疗靶点,已成为基础和临床研究的热点.大量证据表明外泌体在很大程度上参与IHD的演变,包括内皮功能障碍、脂质沉积、动脉粥样硬化斑块的形成和破裂、心肌缺血再灌注损伤和心力衰竭.本篇综述将系统地描述在IHD发展的各个阶段中...
|
| 关 键 词： | 外泌体miRNA 缺血性心脏病 作用机制 治疗靶点 |
| 收稿时间： | 2020/3/27 0:00:00 |
| 修稿时间： | 2020/5/29 0:00:00 |
The mechanism of exosome miRNA in ischemic heart disease and the prospect of targeted therapy |
| |
| YU Xiaopu,BIAN Yunfei,PANG Youcheng,GUO Xunan,WANG Dongying.The mechanism of exosome miRNA in ischemic heart disease and the prospect of targeted therapy[J].Chinese Journal of Arteriosclerosis,2021,29(2):171-178. |
| |
| Authors: | YU Xiaopu BIAN Yunfei PANG Youcheng GUO Xunan WANG Dongying |
| |
| Institution: | (Shanxi Medical University,Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China;Department of Cardiology,Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China) |
| |
| Abstract: | The occurrence of ischemic heart disease(ISH) is a multi-step chain process from a variety of potential risk factors to dominant clinical diseases. Using exosomes as a therapeutic target of ISH has become a hot spot in basic and clinical research. A large number of evidences show that exosomes are involved in the evolution of IHD to a great extent, including endothelial dysfunction, lipid deposition, atherosclerotic plaque formation and rupture, myocardial ischemia-reperfusion injury and heart failure. This review will systematically describe the related roles and mechanisms of various exosomes and their active molecules miRNAs in various stages of IHD development, and also reveal the potential and challenges of exosome miRNAs as therapeutic targets, hoping to provide support for future research. |
| |
| Keywords: | exosome miRNA ischemic heart disease mechanism of action therapeutic target |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国动脉硬化杂志》浏览原始摘要信息 |
| 点击此处可从《中国动脉硬化杂志》下载免费的PDF全文 |
|
