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Prevalence of CXCR4-tropic viruses in clustered transmission chains at the time of primary HIV-1 infection |
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| Authors: | P. Frange L. Meyer J. Ghosn C. Deveau C. Goujard C. Duvivier R. Tubiana C. Rouzioux M.-L. Chaix |
| Affiliation: | 1. EA 3620, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France;2. AP-HP, Hôpital Necker – Enfants Malades, Unité d’Immunologie, Hématologie et Rhumatologie Pédiatriques, Paris, France;3. INSERM, U1018, Service d’Epidémiologie et de Santé Publique, AP-HP, Hôpital de Bicêtre, Université Paris-Sud, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France;4. Centre de Diagnostic et de Thérapeutique, AP-HP, Hôpital de l’Hôtel Dieu, Paris, France;5. Service de Médecine Interne, AP-HP, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France;6. Service des Maladies Infectieuses et Tropicales, AP-HP, Hôopital Necker – Enfants Malades, Centre d’Infectiologie Necker – Pasteur, Institut Pasteur, Paris, France;7. Service de Maladies Infectieuses, AP-HP, Hôpital Pitié Salpêtrière & INSERM, U943, Paris, France;8. Laboratoire de Virologie, AP-HP, Hôpital Necker– Enfants Malades, Paris, France |
| Abstract: | During 2003–2010, 555 strains isolated from sexually-infected patients at the time of primary HIV-1 infection (PHI) were characterized. Tree topology revealed that 11.7% of PHIs segregated into transmission clusters. CXCR4-usage was identified in 27 strains (4.9%) and was significantly associated with subtype B (p 0.003) and low CD4 cell count (p 0.01). In clustered and unique PHIs, the prevalence of CXCR4-tropic strains was 1.5% and 5.3%, respectively (p 0.35). Our results are in line with the hypothesis of a mucosal bottleneck contributing to the high prevalence of CCR5 variants during PHI. |
| Keywords: | CCR5 CXCR4 HIV-1 primary infection transmission clusters |
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