Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia |
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| Authors: | A. Gradíssimo Oliveira C. Delgado N. Verdasca Â. Pista |
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| Affiliation: | 1. National Reference Laboratory of STI for Human Papillomavirus and Genital Herpes Virus, Department of Infectious Diseases, National Institute of Health, Lisbon;2. Department of Bioinformatics and Computational Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras;3. Department of Infectious Diseases, National Institute of Health, Lisbon, Portugal |
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| Abstract: | The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion. |
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| Keywords: | Cervical cancer human papillomavirus 18 molecular marker physical status risk assessment |
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