Rab27b在结直肠癌中的表达情况及临床意义

目的:检测Rab27b在结直肠癌中的表达情况,并探讨Rab27b表达与结直肠癌中重要临床指标尤其是临床预后之间的关系?方法:在组织芯片上(80例肠癌标本及20例癌旁对照标本)进行免疫组化检测,使用Cox回归法及Kaplan-Meier生存分析法进行结直肠癌患者的预后分析?结果:免疫组化结果显示结直肠癌中的Rab27b表达明显高于癌旁对照组Rab27b的表达(P=0.041)?Rab27b的表达与结直肠癌患者的性别(P=0.012)?血清CEA水平(P=0.014)?远处转移(P=0.021)及TNM分期(P=0.013)有重要关联?生存分析显示Rab27b表达(P=0.021)与结直肠癌患者预后关系密切,Rab27b高表达提示预后不良?结论:Rab27b在结直肠癌组织中异常高表达,且Rab27b的表达与结直肠癌的数种恶性表型相关?Rab27b可作为结直肠癌患者预后的独立危险因素?

Expression and clinical significance of Rab27b in colorectal cancer

Objective: To detect the expression of Rab27b in human colorectal cancer (CRC) and investigate the relationship between Rab27b expression and clinical characteristics, especially the prognosis of CRC. Methods: Immunohistochemistry analysis by tissue microarrays (80 CRC samples and 20 tumor-adjacent tissue samples) was performed to characterize Rab27b expression in CRC. Cox regression and Kaplan-Meier survival analyses were carried out to evaluate the prognosis of CRC. Results: Immunohistochemistry analysis showed that the expression of Rab27b in CRC was significantly higher than that in normal tumor-adjacent tissues (P = 0.041). Moreover, the expression level of Rab27b protein in CRC was significantly related to gender (P = 0.012), serum CEA level (P = 0.014), distant metastasis (P = 0.021) and TNM stage (P = 0.013). COX multi-factor analysis showed that Rab27b expression (P = 0.021) could be recognized as an independent prognosis factor for CRC. Conclusion: Rab27b expression was abnormally highly expressed and correlated with malignant phenotypes of CRC. It may serve as a novel prognostic factor for CRC.