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| 利拉萘酯的合成 | |
| 引用本文： | 陶琼华,王绍杰,刘彬彬.利拉萘酯的合成[J].中国医药工业杂志,2004,35(10):578-580. |
| 作者姓名： | 陶琼华 王绍杰 刘彬彬 |
| 作者单位： | 1. 海南通用同盟药业有限公司,海南海口,570310 2. 沈阳药科大学制药工程学院,辽宁沈阳,110016 3. 烟台鲁银药业有限公司,山东烟台,264002 |
| 摘 要： | 用5,6,7,8-四氢-2-萘酚与硫光气反应得到的硫代氯甲酸5,6,7,8-四氢-2-萘酯和2-甲氧基-6-甲胺基吡啶在异丙醇-水中于室温反应2h得到抗真菌药物利拉萘酯,总收率70%. |
| 关 键 词： | 利拉萘酯 抗真菌药物 合成 |
| 文章编号： | 1001-8255(2004)10-0578-03 |
Synthesis of Liranaftate |
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| Authors: | TAO Qiong-Hua WANG Shao-Jie LIU Bin- Bin |
| Institution: | TAO Qiong-Hua1,WANG Shao-Jie2*,LIU Bin- Bin3 |
| Abstract: | Liranaftate was synthesized from 5,6,7,8-tetrahydro-2-naphthol by reaction with CSCl2 to give O-5,6,7,8-tetrahydro-2-naphthyl thiochloroformate, which subjected to acylation with 2-methoxy-6-methylaminopyridine in isopro-panol-H2O for 2h at room temperature in an overall yield of 70%. |
| Keywords: | liranaftate antifungal synthesis |
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