肾移植排斥反应的相关因子表达

CD40通路在同种异体急性、慢性排斥反应的发生，发展过程发挥重要作用。进一步研究CD40通路的免疫学特性，将为探索早期监测预防和控制移植排斥反应开辟新的领域。sCD30作为CD30活化释放入血的活性成分，与CD30具有很好的相关性，在肾移植中sCD30的表达为移植肾急性排斥反应的早期诊断及其与急性肾小管坏死的鉴别提供了一个敏感性、特异性很高的非创伤性检查方法，并为指导术后免疫抑制治疗提供了依据。通过对以上肾移植排斥反应相关因子的研究，能有效预测和预防排斥反应，顺利解决移植免疫反应，提高肾脏移植的成功率和改善移植物远期存活。

Expression of factors associated with renal transplant rejection

CD40 pathway plays an important role in occurrence and development of acute and chronic allograft rejection. Further research on immune characteristics of CD40 pathway will explore new field for investigation of early monitoring, prevention and control of rejection. sCD30 as the active component of CD30 activation and release into blood has good correlation with CD30. Expression of CD30 provides a high sensitive and specific non-traumatic examination method for early diagnosis of acute rejection and its identification with acute tubular necrosis in renal transplantation. It also provides the basis for immunosuppressive therapy after transplantation. Through the above research on factor associated with renal transplant rejection, the rejection can be effectively predicted and prevented, transplantation immunoreaction can be solved, successful rate of renal transplantation will be increased, and long-term survival of graft will be improved.