急性肺损伤和急性呼吸窘迫综合征的预后评估指标

急性肺损伤、急性呼吸窘迫时机体发生一系列的病理生理变化,研究者通过对相关临床、生化指标进行研究发现其中一些指标与预后密切相关.临床指标包括年龄、病因、器官功能不全、免疫抑制等.生化指标包括心功能指标氨基末端脑钠肽前体、心肌酶;凝血纤溶相关指标蛋白C;肺表面活性物质;氧化应激产物:一氧化氮、血管假性血友病因子、炎症因子等.利用这些指标可以判断疾病进展,为指导后续治疗提供依据.

Prognostic indicators of acute lung injury and acute respiratory distress syndrome

A series of pathophysiological changes occur when acute lung injury (ALI) or acute re-spiratory distress (ARDS) happens. Studies have shown that some of the clinical and biochemical indicators are closely related with the prognosis of ALI or ARDS. Clinical indicators including age,etiological factor,or-gan dysfunction, immune suppression, etc. Biochemical indicators include cardiac function-related indicator the amino-terminal pro-brain natriuretic peptide,myocardial enzyme;coagulation and fibrinolysis related indi-cator protein C;pulmonary surfactant;products of oxidative stres s nitric oxide,von Willebrand factor,inflam-matory factors,etc. So it is available to make use of relevant indicators to determine the evolution of the dis-ease and guide follow-up therapy.