| 抗肿瘤中药青龙衣化学成分的研究 |
| |
| 引用本文： | 周媛媛,王栋,牛峰. 抗肿瘤中药青龙衣化学成分的研究[J]. 中草药, 2010, 41(1): 11-14 |
| |
| 作者姓名： | 周媛媛 王栋 牛峰 |
| |
| 作者单位： | 1. 黑龙江中医药大学药学院,黑龙江哈尔滨,150040
2. 哈药集团制药六厂,黑龙江,哈尔,150056 |
| |
| 基金项目： | 黑龙江省研究生创新科研项目(YJSCX2007-0177HLJ) |
| |
| 摘 要： | 目的研究抗肿瘤中药青龙衣的化学成分。方法近年大量的药理实验及临床研究表明青龙衣CHCl3及EtOAc部分具有显著的抗肿瘤作用,且毒性较小。本实验利用硅胶柱色谱和大孔吸附树脂分离化合物,并利用1D-NMR及2D-NMR光谱数据确定了化合物的结构。结果从青龙衣的CHCl3活性部位中分得8个化合物,并分别确定为20(S)-原人参二醇-3-酮(1)、达玛烷-20,24-二烯-3β-醇(2)、茸毛香杨梅酮(galeon)(3)、胡桃宁A(jugla-nin A)(4)、2α,3β,23-三羟基-12-烯-28-齐墩果酸(5)、2α,3β-23-三羟基-12-烯-28-熊果酸(6)、齐墩果酸(7)、熊果酸(8)。结论化合物1为首次从天然资源中分离得到的新天然产物;化合物2及5~8均为首次从胡桃属植物中分离得到,此前未见该属三萜类化合物的报道;化合物3为首次从青龙衣中分离得到。
|
| 关 键 词： | 青龙衣 20(S)-原人参二醇-3-酮 抗肿瘤活性 |
| 收稿时间： | 2009-09-15 |
Studies on constituents from pericarps of Juglans mandshurica with anti-tumor activity |
| |
| ZHOU Yuan-yuan,WANG Dong and NIU Feng. Studies on constituents from pericarps of Juglans mandshurica with anti-tumor activity[J]. Chinese Traditional and Herbal Drugs, 2010, 41(1): 11-14 |
| |
| Authors: | ZHOU Yuan-yuan WANG Dong NIU Feng |
| |
| Affiliation: | ZHOU Yuan-yuan1,WANG Dong1,NIU Feng2(1.College of Pharmacy,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China,2.Harbin Pharmaceutical Group Sixth Pharmaceutical Factory,Harbin 150056,China) |
| |
| Abstract: | Objective To study the chemical components from the pericarps of Juglans mandshurica with anti-tumor activity.Methods It showed that pericarps of J.mandshurica had a good performance in treating cancer and low toxicity from CHCl3 and EtOAc portions by a lot of pharmacological experiments and modern clinical application in the past.Compounds were isolated by chromatography on silica gel columns and AB-8 macroporous resin.On the basis of spectral evidences including 1D-NMR and 2D-NMR,the structures of these c... |
| |
| Keywords: | pericarps of Juglans mandshurica Maxim. 20(S)-protopanaxadiol-3-one anti-tumor activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
|
点击此处可从《中草药》下载全文 |
|
