| 蝙蝠葛苏林碱对映异构体的合成 |
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| 引用本文： | 况代武,孔荣祖.蝙蝠葛苏林碱对映异构体的合成[J].中国药科大学学报,1990,21(6):364-366. |
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| 作者姓名： | 况代武 孔荣祖 |
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| 作者单位： | 中国药科大学制药化学教研室
(况代武，孔荣祖)，中国药科大学制药化学教研室(华维一) |
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| 摘 要： | 蝙蝠葛苏林碱属双苄基四氢异喹啉类生物碱,存在于防己科植物蝙蝠葛的根茎中,由郑锡文等分离得到,并证明结构。华维一等全合成了蝙蝠葛苏林碱并验证了结构。近几年来的药理研究发现,此生物碱为较强的Ca离
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| 关 键 词： | 蝙蝠葛苏林碱 对映异构体 |
Synthesis of Antipode of Daurisoline |
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| Kuang Daiwu,Kong Rongzu,Hua Weiyi.Synthesis of Antipode of Daurisoline[J].Journal of China Pharmaceutical University,1990,21(6):364-366. |
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| Authors: | Kuang Daiwu Kong Rongzu Hua Weiyi |
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| Institution: | Kuang Daiwu,Kong Rongzu,Hua Weiyi Department of Pharmaceutical Chemistry |
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| Abstract: | Daurisoline has been isolated from the plant Mcnispermum dauricum DC. The present investigation describes the total synthesis of antipode of Daurisoline via the optical active compounds (+)-1-(4-hydroxybenzyl)-2-methyl-6, 7-dimethoxy-1, 2, 3, 4-tetrahydroisoquinoline and (+)-7, 4-O, O-dibenzyl-3'-bromo-2-methyl-6-methoxy-1, 2, 3, 4-tetrahydroisoquinoline. IR, NMR, MS of (1a) were completely identical with those of authentic natural sample (1). Circula dichroism spectrum of (1 a) was symmetrical to that of (1). |
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| Keywords: | Daurisoline Antipode |
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