S-100 protein: a prognostic indicator in cutaneous malignant melanoma? |
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Authors: | N.M. KERNOHAN R. RANKIN |
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Affiliation: | Department of Pathology, Univesity of Aberdeen, UK. |
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Abstract: | A series of 215 cases of cutaneous malignant melanoma referred to a single department of clinical oncology between 1940 and 1969 was studied to assess the accuracy of the Breslow thickness and the role of S-100 protein in predicting the clinical prognosis. Histological examination of these tumours showed that although the Breslow thickness correlated well with prognosis, in a significant number of cases it did not reliably forecast clinical outcome. From this series, tissue from those patients who survived disease-free for more than 10 years and those who died within a year of diagnosis was stained immunohistochemically for S-100 protein. Contrary to the findings of earlier studies, strong staining for S-100 protein was associated with improved survival (P less than 0.001). A marked increase in the incidence of cutaneous malignant melanoma was noted during the period of the study. |
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Keywords: | Keywords: S-100 protein cutaneous malignant melanoma prognosis |
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