| 载脂蛋白E多态性与老年冠心病关系的临床研究 |
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| 引用本文： | 张志勉,王秀花,李秀琴,张红雨,高海青.载脂蛋白E多态性与老年冠心病关系的临床研究[J].山东大学学报(医学版),2001,39(4):295-297. |
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| 作者姓名： | 张志勉 王秀花 李秀琴 张红雨 高海青 |
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| 作者单位： | 1. 山东大学齐鲁医院心内科
2. 齐鲁石化公司中心医院 |
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| 基金项目： | 山东省科委资助课题(961226716) |
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| 摘 要： | 目的探讨人载脂蛋白E(apo E)遗传多态性与冠心病的关系.方法采用等电聚焦电泳及免疫印迹法测定102例正常老年人与91例老年冠心病人apoE表型,分析apoE表型与冠心病发病之间的关系.结果冠心病组与正常老年人组apoE表型与apoE等位基因频率分布无显著差异,均以E3/3表型常见和E3等位基因频率最高.结论apoE基因多态性在正常老年人及老年冠心病人之间比较无显著差异.
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| 关 键 词： | 冠状动脉疾病 老年人 载脂蛋白E类 基因型 基因频率 |
| 文章编号： | 1000-0496(2001)04-0295-03 |
| 修稿时间： | 2000年5月8日 |
CLINICAL STUDY OF THE ASSOCIATION BETWEEN APOE POLYMORPHISM AND LIMID METABOLISM IN PATIENTS WITH CHD |
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| ZHANG Zhi mian,WANG Xiu hua,LI Xiu qin,et al.CLINICAL STUDY OF THE ASSOCIATION BETWEEN APOE POLYMORPHISM AND LIMID METABOLISM IN PATIENTS WITH CHD[J].Journal of Shandong University:Health Sciences,2001,39(4):295-297. |
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| Authors: | ZHANG Zhi mian WANG Xiu hua LI Xiu qin |
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| Abstract: | Objective:To study the relationship of the polymorphism of apolipoprotein E(apoE) and coronary heart disease(CHD).Methods:The apoE genotype was determined in 91 CHD patients and 102 healthy old people by isoeletric focusing(IEF) and immunoblotting.Results:The apoE genotypes and the frequencies were no difference between CHD patients and the healthy old people,the genotype E3/3 and the prevalence of E3 allele were significantly higher than those carrying other alleles.Conclusion:There are no significant difference in apoE polymorphysm between the healthy old people and the patients with CHD. |
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| Keywords: | Coronary disease Aged Apolipoproteins E Genotype Gene frequency |
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