Cellulose acetate/chitosan multimicrospheres preparation and ranitidine hydrochloride release in vitro |
| |
| Authors: | Zhou Hui Yun Chen Xi Guang Liu Cheng Sheng Meng Xiang Hong Liu Chen Guang He Jun Yu Le Jun |
| |
| Affiliation: | a College of Marine Life Science, Ocean University of China, Qingdao, P. R. China |
| |
| Abstract: | A noval cellulose acetate/chitosan multimicrospheres (CACM) was prepared by the method of w/o/w emulsion. The concentration of cellulose acetate (CA) and the ratio of CA/chitosan (CS) had influence on the CACM size, and appearance. Ranitidine hydrochloride loading, and releasing efficiency in vitro were investigated. The optimal condition for preparation of the microspheres was CA concentration at 2% and the ratio of CA/CS at 3/1. The microspheres size was 200-350 μm. The appearance of microspheres was spherical, porous, and nonaggregated. The highest loading efficiency was 21%. The ranitidine release from the CACM was 40% during 48 hr in buffers. |
| |
| Keywords: | Cellulose Acetate Chitosan Controlled Release Multimicrosphere Ranitidine Hydrochloride |
| 本文献已被 InformaWorld PubMed 等数据库收录！ |
