1038例矮小症病因及治疗的研究

目的:分析矮小症的病因及治疗特点,为该类患儿的诊断及治疗提供有价值的参考。方法:对1038例矮小儿童(男511例,女527例)进行病因分析,并按是否缺乏生长激素(growth hormone,GH)分为GH缺乏与非GH缺乏两组,分别采用重组人生长激素(rhGH)和非rhGH治疗。结果:1038例患儿中,内分泌疾病所致矮小占大多数,最常见为生长激素缺乏症(growth hormone deficienty,GHD)295例,占28.4%,甲状腺功能低下217例,占20.9%,Turner综合征105例,占10.1%,青春期发育延迟85例,占8.2%,宫内发育迟缓51例,占4.9%,家族性矮小45例,占4.3%,特发性矮小33例,占3.2%,尿崩症伴GHD23例,占2.2%,其余占21.3%。rhGH对GHD治疗效果满意1cm/月左右,非GH缺乏组中甲状腺功能低下予以甲状腺素片加赖氨酸合剂治疗,身高增长迅速,大约1cm/月。结论:矮小原因很多,及时发现病因,寻求最佳治疗手段非常重要。

Etiologic and remedial study of 1 038 children with short stature

Objective:Analyzing the etiological factor and treatment feature of 1 038 children with short stature,to provide a worthy reference of diagnosis and treatment for those type of dwarfisms.Methods:1 038 children were collected ,among them 511 were males (49.22 %) ,527 were females (50.78%) .All of the children were collected detail medical history and taken both physical and laboratory examinations.And they were divided into two groups according to the level of growth hormone,one was GH lack group and the other was non- GH lack group,which were respectively adopted reorganization human growth hormone (rhGH) and non- rhGH treatment.Results:Endocrinopathy could cause short stature.GHD was the most common disease among the 1 038 children.There were 295 cases (28.4%) diagnosed as growth hormone deficiency(GHD),217 cases (20.9 %) hypothyroidism ,105 cases (10.1%) Turner syndrome,85 cases (8.2 %) constitutional delay of growth and puberty,51 cases (4.9 %) intrauterine growth retardation,45 cases (4.3%) familial short stature,33 cases (3.2%) idiopathic short stature,23 cases (2.2%) diabetes insipidus with GHD,the rest (21.3%) were attribute to the other reasons.The rhGH was proved to be an effective and safe drug to treat GHD that the mean height increased about 1.0 cm/month.By treating hypothyroidism cases in the non- GH lack group with Thyroid Tablets and lysine, the same curative effect were gained.Conclusion:According to the pathogeny,selecting correct treatments is the key to treat the short stature children.