α7-烟碱样乙酰胆碱受体基因多态性与精神分裂症的关联研究 |
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引用本文: | 陈元堂,高成阁.α7-烟碱样乙酰胆碱受体基因多态性与精神分裂症的关联研究[J].中华行为医学与脑科学杂志,2008,17(3). |
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作者姓名: | 陈元堂 高成阁 |
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作者单位: | 1. 西安市精神卫生中心 2. 西安交通大学医学院第一附属医院,西安,710061 |
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基金项目: | 陕西省卫生厅资助项目 |
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摘 要: | 目的 研究α7-烟碱样乙酰胆碱受体基因rs1042724,rs384470多态性与精神分裂症的相关性.方法 运用聚合酶链反应扩增及单核苷酸多态性的分子生物学技术,对符合精神分裂症诊断标准的98个先证者及其父母组成的核心家系,测定α7-烟碱样乙酰胆碱受体基因分型,进行精神分裂症的α7-烟碱样乙酰胆碱受体基因多态性的关联分析和传递不平衡(TDT)检验.结果 TDT检验结果提示α7-烟碱样乙酰胆碱受体基因等位基因与精神分裂症之间的相关性(McNemar 2 = 4.21,P<0.05),且等位基因T携带者,其精神分裂症的易患性是C携带者的1.31倍(RR=1.31,2 (RR)=3.96,P<0.05);rs384470位点与精神分裂症不存在关联(McNemar 2 =2.34,P>0.05).结论 提示α7-烟碱样乙酰胆碱受体基因rs1042724与精神分裂症相关联.
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关 键 词: | 精神分裂症 α7-烟碱样乙酰胆碱受体 多态性 关联分析 |
The association between schizophrenia and the nicotine-like acetylcholinergic receptor gene polymorphism |
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Authors: | CHEN Yuan-tang GAO Cheng-ge |
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Abstract: | Objective To detect the genetic association between schizophrenia and rs1042724,rs384470 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene. Methods Observed in a sample of 98 parent/offspring trios where the proband net the American Classification and diagnostic Criteria for Mental Disorders. The Forth Revised Edition, criteria for schizophrenia using transmission/disequilibrium test(TDT) analysis. The polymorphism of nicotine-like acetylcholinergic receptor gene was detected with PCR methods and SNP typing in all nucleus families. Results Using a family-based association design we obtained evidence of an association between schizophrenia and allele of the rs1042724 polymorphism in the nicotine-like acetylcholinergic receptor gene(RR=1.31,2 (RR)=3.96,P<0.05). Moreover the fact that transmission disequilibrium was observed when one affected offspring was selected at random from each family, suggesting that the results are due to association(McNemar 2 = 4.21,P<0.05). There is no association between schizophrenia and rs1042724 polymorphism in the nicotine-like acetylcholinergic receptor gene (McNemar 2 =2.34,P>0.05). Conclusion It shows an association between schizophrenia and the rs1042724 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene in Chinese. |
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Keywords: | Schizophrenia The α7 nicotine-like acetylcholinergic receptor gene Polymorphism Association analysis |
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