氧化应激与糖尿病并发症发生的相关性研究

目的探讨糖尿病患者氧化应激与糖尿病及其并发症的发生和进展的关系。方法检测糖尿病（DM）组、糖尿病肾病（DN）组、糖尿病视网膜病变（DR）组、糖尿病足（DF）组、糖尿病神经病变（DNP）组和对照组24h尿8-羟基脱氧鸟苷酸（8-OhdG）的含量，并作统计学分析。结果DM组、DN组、DR组、DF组、DNP组24h尿8-OhdG含量明显高于对照组（P〈0．01），而DN组、DR组、DF组、DNP组24h尿8-OhdG含量高于DM组（P〈0．01），且DN组、DR组、DF组、DNP组之间24h尿8-OhdG含量没有统计学意义（P〉0．05）。结论糖尿病及其并发症的发生与机体的氧化应激水平呈正相关。

Study on the correlation between oxidative stress and diabetic complications

Objective To explore the correlation between oxidative stress and the occurrence and progression of diabetic complications in the patients with diabetes. Methods The content of 24 h urinary 8-hydroxy-deoxyguanosine (8-OhdG) in diabetes mellitus (DM) group, diabetic nephropathy (DN) group, diabetic retinopathy (DR)group, diabetic foot(DF) group, diabetic neuropathy (DNP) group and control group were detected, and analyzed. Results The content of 24 h 8-OhdG in DM group, DN group, DR group, DF group, DNP group were significantly higher than that in the control group (P ＜ 0.01), and that in DN group, DR group, DF group, DNP group were significantly higher than that in DM group(P ＜ 0. 01), but the content of 24 h 8-OhdG among DN group, DR group, DF group and DNP group was not statistically signiticant(P ＞0. 05). Conclusion The correlation between the occurrence of diabetic and its complications oxidative stress and the Ievel of oxidative stress in the body was positive related.