异丙肌苷对小鼠免疫功能的增强作用 |
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引用本文: | 林志彬,马莉,夏冬.异丙肌苷对小鼠免疫功能的增强作用[J].中国药理学通报,1989(5). |
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作者姓名: | 林志彬 马莉 夏冬 |
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作者单位: | [1]北京医科大学药理学教研室 [2]北京医科大学基础医学专业82级 [3]100083 |
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摘 要: | 在正常小鼠和注射环磷酰胺所致的免疫功能抑制的小鼠,异丙肌苷)25,50,100mg/kg,ip)能显著促进溶血素生成;增加空斑形成细胞数;增强二硝基氯苯所致迟发型皮肤超敏反应。在16月龄老年小鼠,异丙肌苷(2.5mg/kg,ip)可使减少的空斑形成细胞数增加至接近3月龄小鼠的水平,加大剂量作用反减弱或使空斑形成细胞数显著减少。体外试验,异丙肌苷(5,10,20mg/L)可显著增强刀豆素A诱导的C57 BL/6J小鼠的淋巴细胞增殖反应,并使16月龄老年小鼠低下的刀豆素A诱导的淋巴细胞增殖反应明显恢复。
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关 键 词: | 异丙肌苷 环磷酰胺 溶血素 空斑形成细胞 迟发型皮肤 超敏反应 淋巴细胞增殖反应 老年免疫缺陷 |
POTENTIATING EFFECT OF ISOPRINOSINE ON IMMUNE RESPONSES IN MICE |
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Abstract: | Isopinosine (ISO, 25·100 mg/kg·d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide. In 16 month aged mice, ISO (ip for 5 d) showed potentiating effect on anti-SRBC PFC response at the dose of 2 .5 mg/kg, no significant effect at the dose of 5 .0 mg/kg, and inhibiting effect at the dose of 25 and 100 mg/kg respectively. 1SO(25,50 and 100 mg/kg·d-1 ip for 9 or 10 d ) remarkably enhanced delayed cutaneous hypersensiti-vity (DCH) to 2, 4 -dinitrochlorobenzene (DNCB) in normal mice as well as in immunosuppressive mice induced by cyclophospha-mide. ISO (5, 10 and 20 mg/L ) signficantly increased ConA-induced lymphocyte proliferation of spleen cells from C57BL/6J mice in vitro. There was also potentiating effect on lymphocyte proliferation induced by ConA in 16 month aged mice. |
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Keywords: | Isoprinosine Cyclophosphamide Hemolysin Plaque forming cell ( PFC ) Delayed cutaneous hepersensitivity ( DCH ) Lymphocyte proliferation Aged immunodeficiency |
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