Partial monosomy 5p and partial trisomy 5q due to paternal pericentric inversion of chromosome 5 |
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Authors: | Kazuhiro Ono Yasushi Ohashi Hisashi Nakano Hirosuke Togashi Yoji Kannari Shinsaku Isono |
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Affiliation: | (1) Second Department of Oral and Maxillo-facial Surgery, School of Dentistry, Niigata University, Gakkocho-dori, 951 Niigata, Japan |
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Abstract: | Summary A male infant with partial monosomy 5p and partial trisomy 5q due to paternal pericentric inversion of chromosome 5 (46,XY,rec(5), dup q,inv(5)(p15.1q35.1)pat) is reported together with the oral findings. The phenotype was chiefly the cri-du-chat syndrome. Severe retardation of mental and motor development, microencephaly, cardiac malformation, crying and facial appearance unique to the cri-du-chat syndrome were observed. Perioral and intraoral findings included thin upper lip, downturning corners of mouth, micrognathia, shallow palate, and cleft of soft palate. Anterior deciduous teeth were small and canine deciduous teeth were conic. The row of deciduous teeth showed a flat arch-like shape that was very wide but short in length. No abnormality was noted in the number of deciduous teeth or the timing of eruption. |
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Keywords: | pericentric inversion recombinant chromosome double aneuploidy partial monosomy 5p partial trisomy 5q |
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